01.06.12+-+Cholesterol


 * Cholesterol**


 * 1. Be able to describe how cholesterol regulates HMG CoA reductase and LDL receptor function**


 * 2. List the number of carbons and order of formation of the following compounds in the cholesterol biosynthetic pathway: squalene, mevalonate, HMG CoA, cholesterol, isopentenyl-pyrophosphate**


 * 3. List and describe the function for six products of the polyisoprenoid biosynthetic pathway in humans**


 * 4. Describe the function and tissue localization of the following in cholesterol transport: LDL, HDL, LDL receptor, chylomicron remnant receptor, and the scavenger receptor**


 * 5. Structurally and functionally differentiate the following structures:asteroid hormone, cholesterol, a cholesterol ester, and vitamin D 3 **


 * 6. Be able to discuss the different functions of the liver in cholesterol homeostasis**


 * 7. Know the four categories of steroid hormones, an example of each, and the role of desmolase and cytochrome P450 monoxygenases in their synthesis**


 * 8. Know the general scheme of feedback of regulation of cortisol synthesis.**