01.09.12+-+Oxygen+Metabolism


 * Oxygen Metabolism**


 * 1. Be able to name and write three partial reduction products of molecular oxygen. Define "Oxygen-Free Radical" and “Reactive Oxygen Species”**


 * 2. Name and distinguish by substrate and product three classes of enzymes that use molecular oxygen**


 * 3. Be able to write the generalized reaction catalyzed by cytochrome P450and explain its role in drug and lipid metabolism**


 * 4. Know the source of nitrogen and oxygen atoms and physiological role of NO**


 * 5. Know the role of Fe+3 in hydroxyl free radical formation. Know the most important source of superoxide within cells**


 * 6. Know the role (substrate and product, subcellular location) of the enzymes superoxide dismutase, catalase, and glutathione peroxidase in ameliorating oxidative stress. Know the role of vitamins E and C in protection against oxidative stress**


 * 7. Identify the cellular location of the electron transfer protein that participates in NADPH oxidation of the respiratory burst pathway and be able to explain the clinical significance of this pathway in chronic granulomatous disease and cellular defense mechanisms**


 * 8. List three measurable effects of oxidative damage in humans. Know what is meant by “methemoglobin”.**


 * 9. Know what is meant by the oxidative stress theory of aging.**