11.17.11+-+Lymphoid+System

I only did a few questions

The Immune System is synonymous with the Lymphoid System. It distinguishes and organism’s “self” molecules from foreign molecules. It neutralizes/inactivates foreign molecules It destroys microorganisms, infected cells, cells of transplanted organs(bad), and cancer cells (good) --it’s comparative to the customs and immigration dept at the airport (they screen for unwelcome foreigners, but also sometimes mess up and are jerks to you even if you’re a citizen)
 * 1. General Functions of the Immune System **

The immune system has two forms of response (1) Innate (2) Adaptive

It’s the first line of defense and the more primitive of the two responses. It’s a non-specific/generic response that is more immediate. Major cells involved: Neutrophils react first and later on Macrophages, eosinophils and NK cells will also be directly involved in killing pathogens.
 * 2. Describe innate immune response **


 * 3. Define in general terms **
 * PAMP ** = pathogen associated molecular pattern. PAMPs are molecules associated w/ groups of pathogens that are recognized by the innate immune system. Would be something like seeing a flagella or bacterial plasma membrane. May clear an infection before the adaptive response is activated.


 * DAMP ** = damage associated molecule pattern. Induces inflammation when there is tissue damage (a bruise). In reality the DAMP pattern would consist of seeing a nucleus or cytoplasmic contents outside of a cell (it's unusual and your body knows that its not normal) It’s a precaution against undetected inflammation (which I think means that even if the body hasn’t received major signals that there is damage, the DAMPs will tip off the immune system that there is a problem)

(ex: you see a naked person on a bike…suspicious and unusual!…seeing that makes you wonder “is it Portland’s Naked Bike Ride Day?” so you now suspect there is a larger source of naked bike riders roaming around somewhere…which is something you should probably check out… a PAMP bike rider would have bat or chain which would make you suspect that naked bike ride day has gotten violent so you’ll assemble a task force to stop evil naked bike riders…a DAMP bike rider would be bloody which would mean that the naked bikers all crashed so your reaction would be to assemble a task force to start taking care of the injured.)


 * Autoinflammation ** - mutations in the signaling pathways that induce inflammation cause the body to produce either overproduce signals when there is damage or produce signals when there is actually no damage—either way the body over-reacts by inflaming.